Additional Resources
Browse these research studies to learn more about knowledge and theories behind the iO-Core procedure.
- Subchondral Stem Cell Therapy Versus Contralateral Total Knee Arthroplasty for Knee Osteoarthritis Following Secondary Osteonecrosis of the Knee
- The Results of Core Decompression Treatments in Patients With Avascular Necrosis of Femoral Head in Patients at Isfahan City Educational Hospitals in 2010-2011
- Increase in Bone Marrow Lesions Associated With Cartilage Loss: A Longitudinal Magnetic Resonance Imaging Study of Knee Osteoarthritis
- Bone Marrow Edema: Chronic Bone Marrow Lesions of the Knee and the Association with Osteoarthritis
- Intraosseous Hypertension and Pain in the Knee
- Treatment of Osteonecrosis With Autologous Bone Marrow Grafting
- Cell Therapy Versus Simultaneous Contralateral Decompression in Symptomatic Corticosteroid Osteonecrosis: A Thirty Year Follow-Up Prospective Randomized Study of One Hundred and Twenty Five Adults
- Bone Marrow Lesions Predict Increase in Knee Cartilage Defects and Loss of Cartilage Volume in Middle-Aged Women Without Knee Pain Over 2 Years CDC
- Arthritis-Related Statistics
Home Page *
- Collins et al. (2016) Bone Marrow Edema: Chronic Bone Marrow Lesions of the Knee and the Association with Osteoarthritis. Bull Hosp JT Dis (2013). 2016 Mar;74(1):24-36.
- Eriksen et al. (2015) Treatment of bone marrow lesions (bone marrow edema). Bonekey Rep. 2015 Nov 25;4:755
- Osteoarthritis as a Whole Joint Disease A. Robin Poole, PhD, DSc
- Loeser, Richard F et al. “Osteoarthritis: a disease of the joint as an organ.” Arthritis and rheumatism vol. 64,6 (2012)
- Medvedeva EV, Grebenik EA, Gornostaeva SN, et al. Repair of Damaged Articular Cartilage: Current Approaches and Future Directions. Int J Mol Sci. 2018
- Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis Mary B. Goldring Steven R. Goldring 2010
- Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations. Dragan Primorac 2020
- Felson DT, Chaisson CE, Hill CL et al. The Association of Bone Marrow Lesions with Pain in Knee Osteoarthritis. Ann Intern Med. 2001;134(7):541– 549.
- Bone marrow lesions: a universal bone response to injury? Erik Fink Eriksen & Johan Diederich Ringe Rheumatology International volume 32, pages575–584(2012)
- Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging. David T. Felson 2007
- Driban, J.B., Price, L.L., Lo, G.H. et al. Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker – longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative. Arthritis Res Ther 15, R112 (2013).
- Lo GH, McAlindon TE, Niu J, et al. Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2009;
- Osteoarthritis: A Critical Review. Onishi, K., Utturkar, A., Chang, E., Panush, R., Hata, J., & Perret-Karimi, D. (2012).
- Meniscal pathology on MRI increases the risk for both incident and enlarging subchondral bone marrow lesions of the knee: the MOST Study. Martin Englund, MD, PhD 2010
Procedure Page*
- Baumbach SF, Pfahler V, Bechtold-Dalla Pozza S, et al. How We Manage Bone Marrow Edema-An Interdisciplinary Approach. J Clin Med. 2020
- Felson DT, Chaisson CE, Hill CL et al. The Association of Bone Marrow Lesions with Pain in Knee Osteoarthritis. Ann Intern Med. 2001;134(7):541– 549.
- Bone marrow lesions: a universal bone response to injury? Erik Fink Eriksen & Johan Diederich Ringe Rheumatology International volume 32, pages575–584(2012)
- Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging. David T. Felson 2007
- Driban, J.B., Price, L.L., Lo, G.H. et al. Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker – longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative. Arthritis Res Ther 15, R112 (2013).
- Lo GH, McAlindon TE, Niu J, et al. Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2009;
FAQ Page*
- Berstock JR, Beswick AD, Lenguerrand E, Whitehouse MR, Blom AW. Mortality after total hip replacement surgery: A systematic review. Bone Joint Res. 2014
- Long-term Benefit of Steroid Injections for Knee Osteoarthritis Challenged By Kirstie Saltsman, Ph.D. | October 12, 2017
- Cortisone Shots
- Felson DT, Chaisson CE, Hill CL et al. The Association of Bone Marrow Lesions with Pain in Knee Osteoarthritis. Ann Intern Med. 2001;134(7):541– 549.
- Bone marrow lesions: a universal bone response to injury? Erik Fink Eriksen & Johan Diederich Ringe Rheumatology International volume 32, pages575–584(2012)
- Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging. David T. Felson 2007
- Driban, J.B., Price, L.L., Lo, G.H. et al. Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker – longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative. Arthritis Res Ther 15, R112 (2013).
- Lo GH, McAlindon TE, Niu J, et al. Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2009;